Ingrid Jolly Trayfors: ID#153675


Research Study

The emerging role of flavonoid-rich cocoa and chocolate in cardiovascular health and disease

Engler MB, Engler MM.
Department of Physiological Nursing, Laboratory of Cardiovascular Physiology, University of California, San Francisco, California.

ABSTRACT: Cocoa and chocolate have recently been found to be rich plant-derived sources of antioxidant flavonoids with beneficial cardiovascular properties. These favorable physiological effects include: antioxidant activity, vasodilation and blood pressure reduction, inhibition of platelet activity, and decreased inflammation. Increasing evidence from experimental and clinical studies using cocoa-derived products and chocolate suggest an important role for these high-flavanol-containing foods in heart and vascular protection.

Nutrition Reviews, 2006 Mar;64(3):109-118.



Research Study

Effect of dark chocolate on arterial function in healthy individuals

Vlachopoulos C, Alexopoulos N, Stefanadis C.
Hypertension Unit and Peripheral Vessels Unit, 1st Cardiology Department, Athens Medical School, Athens, Greece.

ABSTRACT: Cocoa has been consumed for at least 2500 years, and for a long time it has been regarded as a medicine. Arterial function is of paramount importance for the proper function and integrity of the cardiovascular system. Dark chocolate and flavonoid-rich cocoa have beneficial acute and short-term effects on endothelial function and wave reflections in normal individuals, in adults with cardiovascular risk factors, and in patients with coronary artery disease. Furthermore, dark chocolate and flavonoid-rich cocoa may have a blood pressure-lowering effect. These effects can be attributed to flavonoids and are mainly mediated through increased nitric oxide bioavailability. Further research is needed to demonstrate whether these effects of chocolate on arterial function are translated into clinical benefit.

Current Hypertension Reports, 2006 Jun;8(3):205-11.



Research Study

Cocoa and chocolate flavonoids: implications for cardiovascular health

Steinberg FM, Bearden MM, Keen CL
Didactic Program in Dietetics, Department of Nutrition, University of California, Davis, California.

ABSTRACT: This paper offers a review of current scientific research regarding the potential cardiovascular health benefits of flavonoids found in cocoa and chocolate. Recent reports indicate that the main flavonoids found in cocoa, flavan-3-ols and their oligomeric derivatives, procyanidins, have a variety of beneficial actions, including antioxidant protection and modulation of vascular homeostasis [balance between blood clot formation and prevention]. These findings are supported by similar research on other flavonoid-rich foods. Other constituents in cocoa and chocolate that may also influence cardiovascular health are briefly reviewed. The lipid content of chocolate is relatively high; however, one third of the lipid in cocoa butter is composed of the fat stearic acid, which exerts a neutral cholesterolemic response in humans. Cocoa and chocolate contribute to trace mineral intake, which is necessary for optimum functioning of all biologic systems and for vascular tone. Thus, multiple components in chocolate, particularly flavonoids, can contribute to the complex interplay of nutrition and health. Applications of this knowledge include recommendations by health professionals to encourage individuals to consume a wide range of phytochemical-rich foods, which can include dark chocolate in moderate amounts.

Journal of the American Dietetic Association, 2003 Feb;103(2):215-23.



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